Freeze-Drying Technology Of Biological Samples

Freeze-Drying Technology of Biological Samples

We are a professional R&D and manufacturer of freeze-drying equipment, a professional manufacturer with a complete product line of freeze-dryers for household, pilot-scale to industrial production (pharmaceutical, food), with 15 years of product design and manufacturing experience , The products are sold at home and abroad. The conventional freeze-drying model can meet the needs of most laboratories for routine freeze-drying biological samples. It is rich in configuration, easy to operate, and has a high cost performance.

Drying is one of the ways to preserve items. Conventional methods such as sun-drying, drying, and vacuum drying are carried out at temperatures above 0°C or higher. The preferred method for preservation of biological samples is vacuum freeze-drying. Lyophilized for short, also called sublimation drying.

Under a certain pressure and temperature, water can coexist in three states: solid, liquid and gaseous. This point is called the triple point. Freeze-drying technology usually freezes a substance containing a large amount of water into a solid in advance, and then sublimates the water vapor directly from the solid under a certain vacuum condition, while the substance itself remains in the ice shelf when it is frozen, so it is dried after drying. The original chemical structure and morphology of the solute will not be destroyed, and the biologically active material can still restore the conformation and biological function before freeze-drying after redissolving. Therefore, lyophilization is the safest drying method with the least influence on the properties of the dried material. The Freeze-Drying Technology of Biological Samples has the following advantages:

1. It is suitable for many heat-sensitive substances, such as proteins and microorganisms, without denaturation or loss of biological activity;

2. The loss of some volatile components in the substance is very small, which is suitable for drying some chemical products, medicines, and food;

3. The growth of microorganisms and the action of enzymes cannot be carried out, so the original characters can be maintained;

4. Due to the drying in the frozen state, the volume is almost unchanged, the original structure is maintained, and no concentration phenomenon occurs;

5. The dried material is loose and porous, in the form of a sponge, dissolves rapidly and completely after adding water, and restores its original shape almost immediately;

6. Since the drying is carried out under vacuum, there is very little oxygen, so some easily oxidized substances are protected;

7. It can remove more than 95-99% of the water, so that the dried product can be stored for a long time without deterioration.

At present, freeze-drying technology is widely used in the scientific research and production of medicine, food and other industries, such as biological products, biochemical drugs; microorganisms and algae; and drying operations of some fragile and easily oxidized substances, such as biological specimens and biological tissues, Historical archives, dehumidification preservation of cultural relics, dehumidification of microporous parts, etc.

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